Male hypogonadism: Symptoms and treatment
by Admin
Posted on 22-04-2023 10:34 AM
Hypogonadism in older men is a syndrome characterized by the presence of low testosterone levels and clinical signs and symptoms of hypogonadism. The symptoms of hypogonadism can include decreased libido, impaired erectile function, muscle weakness, increased adiposity, depressed mood, and decreased vitality.
Hypogonadism is more common in aging men and is is also referred to as late-onset hypogonadism (loh) [ 1 ], androgen deficiency in the aging male (adam) [ 2 ], partial androgen deficiency in the aging male (padam) [ 3 ], testosterone deficiency syndrome (tds) [ 4 ], and andropause [ 5 ]. We prefer loh over the other descriptors.
This man presents with non-specific symptoms including fatigue, low energy and low motivation. In the european male ageing study (emas), there was no syndromic association between fatigue and serum testosterone ( 3 ). In the testosterone trials (t-trials), a large rct of 790 men aged 65 years and older with serum testosterone of <9. 5 nmol/l, testosterone treatment did not improve vitality ( 4 ). Therefore, his fatigue and low energy are not expected to improve with testosterone therapy. These symptoms are likely multifactorial. They may be linked to his recent retirement. He should be screened for depression, and other potential contributors to his non-specific symptoms, such as obstructive sleep apnoea (denial of symptoms does not reliably exclude sleep apnoea), should be explored. https://vigrxofficialstore.wordpress.com/
What you need to know about male hypogonadism
New draft industry guidance from the u. S. Food and drug administration (fda) underscores the importance of randomized, double-blind, placebo-controlled trials to establish the efficacy of drugs to treat male hypogonadotropic hypogonadism when it is caused by obesity or another acquired condition. The draft guidance also asserts the potential importance of patient-reported outcome (pro) instruments to such efficacy determinations, since they offer “direct evidence of how patients feel or function. ”male hypogonadism is marked by low concentrations of serum testosterone. There are two forms of hypogonadism, differentiated by serum concentrations of gonadotropins, the hormones that stimulate the gonads—in men, the testes.
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You and Your Hormones
Hypogonadism (hg) in men is characterized by a marked reduction or deficiency in the production of serum testosterone. Men with hg may present clinically with various signs or symptoms. These may include low libido, decreased muscle strength and physical function, loss of energy, depressed mood, and impaired cognition citation[1-3]. Although not generally considered signs of low testosterone, numerous comorbidities have been associated with low testosterone, including abdominal obesity citation , citation , markers of pre-diabetes (insulin resistance, impaired glucose tolerance, and metabolic syndrome) citation , citation , and type 2 diabetes citation[6-9]. Elevated risk of mortality in men with low testosterone levels has been reported in some citation[10-13] but not all studies citation[14-16]. https://vigrxofficialstore.wordpress.com/