PROSTATE CANCER AND LOWER URINARY TRACT SYMPTOMS
Historically, the concern for trt was its effect on the prostate. Despite evidence that the prostate does enlarge slightly on trt, no studies
have shown any significant worsening of urinary symptoms while on therapy. Studies have also demonstrated no significant change in psa while on therapy. An increasing psa while on trt may indicate underlying malignancy and warrants evaluation. There has been no increased risk of prostate cancer demonstrated with trt. Additionally, studies have demonstrated no increased risk of recurrence in men on trt after undergoing treatment for prostate cancer. Small studies of men with active prostate cancer have shown no progression of disease on trt.![caused](https://img.medscapestatic.com/article/824/046/Slide6.png)
Counseling Regarding Treatment of Testosterone Deficiency
A high incidence of ed in ihh men, at comparable levels in ks and nihh, was observed in the present
study
. According to the iief-5 results, as much as 53. 2% of ihh males reported ed.
Research suggests that gnrh-deficient males on hrt may experience minor ed and poorer orgasmic experiences; however, adjustments for anxiety and depression reduce such differences to insignificant levels [ 17 , 29 ]. In our study, patients with ed were worse off not only on the 15d dimension of sexual activity, but also of vision, depression, distress and vitality, and reported lower ss ( table 4 ).
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1. Morgentaler a, zitzmann m, traish am, et al. Fundamental concepts regarding testosterone deficiency and treatment: international expert consensus resolutions. Mayo clin proc. 2016;91(7):881–896. Crossref , medline , google scholar
crossref cas pubmed google scholar basaria s, coviello ad, travison tg, storer tw, farwell wr, jette am, eder r, tennstedt s, ulloor j, zhang a, choong k, lakshman km, mazer na, miciek r, krasnoff j, elmi a, knapp pe, brooks b, appleman e, aggarwal s, bhasin g, hede-brierley l, bhatia a, collins l, lebrasseur n, fiore ld, bhasin s. Adverse events associated with testosterone administration. N engl j med. 2010;363(2):109–22. Basualto-alarcon c, varela d, duran j, maass r, estrada m. Sarcopenia and androgens: a link between pathology and treatment. Front endocrinol (lausanne). 2014;5:217. Berkovitch m, bistritzer t, milone sd, perlman k, kucharczyk w, olivieri nf.
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