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Over time, the brain adjusts to the extra dopamine, reducing the high relative to the high experienced when initially taking the drug—an process called as tolerance. They may take more of the medicine in an attempt to attain the same dopamine high.
Important points to remember: Addiction is a chronic disease that involves excessive drug seeking and use, even though the negative effects can be difficult to control.

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The brain adapts to drugs by decreasing the ability of reward circuit cells to respond when an individual continues to use them. As long as an individual continues to use drugs, this will continue. Tolerance, also known as tolerance, is a process that reduces the person's experience with the drug. The individual might try to get the same high by taking more of the drug. These brain alterations can cause an individual to lose pleasure in activities that they used to enjoy, such as eating or sexual activity.
Don't Wait; Get Help Now. Talk to your doctor if you feel your drug use is becoming too much or causing you problems. Recovering from drug addiction can take time. There is no cure but there are ways to get sober. The therapy you choose could include either counseling or drugs. Talk to your doctor to determine the best plan.

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How to Avoid Addiction to Prescription painkillers. Most people who are prescribed pain medication by their doctor don't develop an addiction. Do not be discouraged from using painkillers to relieve your pain. If you are a convicted drug or alcohol user in the past or have relatives who have, your chances of getting addicted to drugs may increase.
Biology. Biology. The risk of developing a drug addiction and using it can be increased by factors such as gender, race, or the presence of mental disorders.

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Addiction is a chronic disorder that involves excessive drug seeking and abuse, regardless of its negative effects on one's physical health. It can be difficult to stop an addict. Although most people will take drugs out of a desire to do so, it can be difficult to control addiction. Chronic drug abuse can lead to brain changes that make it more difficult to exercise self-control. This can also hinder an individual's ability to resist the urge to use drugs. Because these brain changes can last a long time, drug addiction is known as a "relapsing disorder". People who have recovered from drug addiction are more likely to relapse, even after having stopped using drugs for a while.
To avoid dependence on pain medication, take the prescribed drug exactly as directed by your doctor. Inform your doctor about any drug addiction or misuse in your family. This will allow them to recommend the most effective medication for you.

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When you use drugs for a long period, it might create alterations in other brain chemical processes and circuits as well. They have the potential to impair your judgement, ability to make decisions, memory, and ability to learn. These brain alterations, when combined, can make it difficult for you to resist the temptation to seek out and use drugs in ways that are beyond your control.
Biology. A person's genetic makeup can affect half of their chances of falling prey to addiction. Drug use and addiction risk can also depend on the person's gender, their race, and whether they have any mental disorders.

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When a person takes drugs, the brain adjusts by decreasing the ability of reward circuit cells to respond to it. The individual will experience a lower level of high after using the drug than when they first started. This phenomenon is known as tolerance. They can take more of the drug to achieve the same effect. This brain change can often lead to a person's ability not to enjoy previously enjoyable activities such as eating, sex, and social interactions decreasing with time.
What effects does drug use have on the brain?

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Also, addiction is not the same as tolerance or physical dependence. Withdrawal symptoms occur when you abruptly stop taking a substance. Tolerance happens when a drug's efficacy decreases over time.
Over time, the brain adjusts to the extra dopamine, which lessens the high that the person feels relative to the high they felt when initially taking the drug—an process known as tolerance. They could take more of the medicine, hoping to obtain the same dopamine high.